Product description
(+-)-Synephrine is an alkaloid with vasoconstrictor and metabolic activities.{53000,53001,53002} It binds to a1A-, a2A-, and a2C-adrenergic receptors (ARs; Kis = 78, 36.7, and 24.4 µM, respectively).{53003} (+-)-Synephrine is an agonist of a1A-ARs in HEK293 cells (EC50 = 4 µM in a reporter assay) but not in CHO cells expressing a2A- or a2C-AR. It also acts as an antagonist of a1A-, a2A-, and a2C-ARs, inhibiting L-phenylephrine-induced activation of a1A-AR in HEK293 cells and activation of a2A- and a2C-ARs induced by the a2-AR agonist medetomidine in CHO cells (IC50s = 12.8, 26, and 27.3 µM, respectively, in reporter assays). (+-)-Synephrine induces contractions in isolated rabbit aortic rings (EC50 = 6.2 µg/ml) and increases ligation-induced mean arterial pressure in rats when administered at a dose of 2 mg/kg per day.{53000,53004} It induces lipolysis in isolated rat and human adipocytes when used at concentrations of 100 and 1,000 µg/ml.{53001} (+-)-Synephrine (50 µM) increases phosphorylation of Akt and AMP-activated protein kinase (AMPK) and translocation of Glut4 to the plasma membrane, as well as increases insulin-induced glucose consumption in L6 muscle cells when used at concentrations ranging from 25 to 200 µM.{53002}
Specifications
CAS number
5985-28-4
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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(+-)-Synephrine (hydrochloride)

28398-10

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