Product description
10’-Desmethoxystreptonigrin is an antibiotic originally isolated from Streptomyces and a derivative of the antibiotic streptonigrin.{49160} It is active against a variety of bacteria, including S. aureus, S. faecalis, E. coli, K. pneumoniae, and P. vulgaris (MICs = 0.4, 1.6, 3.1, 3.1, and 0.4 µg/ml, respectively).{49161} 10’-Desmethoxystreptonigrin is cytotoxic to HCT116 colon and A2780 ovarian cancer cells (IC50s = 0.004 and 0.001 µg/ml, respectively), as well as HCT116 cells resistant to etoposide (Item No. 12092) and teniposide (Item No. 14425) and cisplatin-resistant A2780 cells (IC50s = 0.003, 0.001, and 0.01 µg/ml, respectively). 10’-Desmethoxystreptonigrin is also an inhibitor of p21ras farnesylation (IC50 = 21 nM).
Specifications
CAS number
136803-89-9
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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10'-Desmethoxystreptonigrin

28065-2.5

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10'-Desmethoxystreptonigrin

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