2-O-Acetyl-20-hydroxyecdysone

2-O-Acetyl-20-hydroxyecdysone is an ecdysone steroid hormone that has been found in plants and animals.{46337} It completely inhibits the growth of the bacteria S. aureus, E. coli, and P. vulgaris, as well as the fungi C. albicans, A. alternata, and F. solani when used at a concentration of 10 µg/ml. 2-O-Acetyl-20-hydroxyecdysone (50 µM) increases aggregation of amyloid-B (1-42) (AB42), increases fibril formation by 60%, and decreases oligomer levels in cell-free assays.{46338} It reduces AB42-induced cytotoxicity of SH-SY5Y cells when used at concentrations of 5 and 10 µM.