Product description
5'-Deoxy-5'-methylthioadenosine-d3 (MTA-d3) is intended for use as an internal standard for the quantification of MTA (Item No. 15593) by GC- or LC-MS. MTA is an intermediate in the generation of adenine and methionine that is produced by the decarboxylation of S-adenosylmethionine.{25496} This nucleoside is a potent agonist of adenosine receptors (Kis = 0.15, 1.13, 13.9, and 0.68 ?M for A1, A2A, A2B, and A3, respectively).{25499} At higher concentrations, MTA inhibits several enzymes, including protein carboxylmethyltransferase (Ki = 41 ?M), S-adenosylhomocysteine hydrolase, SET methyltransferases, and spermidine and spermine synthases.{25497,25496,16624,25500}
Specifications
CAS number
174838-38-1
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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5'-Deoxy-5'-methylthioadenosine-d3

27836-1

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