Product description
(+-)-Baclofen-d4 is intended for use as an internal standard for the quantification of (+-)-baclofen (Item No. 18600) by GC- or LC-MS. (+-)-Baclofen is a GABAB receptor agonist (IC50 = 180 nM).{46227} It induces norepinephrine release from isolated rat atria (IC50 = 4.5 ?M). (+-)-Baclofen (10 mg/kg) increases muscle rigidity in spastic mice.{30075} It inhibits the norepinephrine-induced group II flexor reflex in anesthetized rats.{30078} (+-)-Baclofen also reduces cocaine-induced hyperlocomotion in rats and binge-like ethanol intake in mice.{30076,30077} Formulations containing baclofen have been used to treat muscle spasms caused by multiple sclerosis and spinal cord injury.
Specifications
CAS number
1189938-30-4
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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