Product description
(Z)-Ligustilide is a phthalide that has been found in A. graveolens and T. montana roots and has diverse biological activities.{48404,48405,48406,48407} It inhibits autophagy and restores Nurr77 expression and sensitivity to tamoxifen (Item No. 13258) in tamoxifen-resistant MCF-7 cells.{48405} (Z)-Ligustilide (8-32 mg/kg) increases cerebral expression of Nrf2 and HO-1 and reduces infarct volume and neuronal loss in a rat model of cerebral ischemia and reperfusion injury.{48408} It decreases mechanical and thermal hyperalgesia in a rat model of inflammatory pain induced by complete Freund's adjuvant (CFA).{48406} (Z)-Ligustilide restores gait coordination, reduces spinal cord inducible nitric oxide synthase (iNOS) expression, and inhibits production of prostaglandin E2 (PGE2; Item No. 14010), TNF-a, and IL-1B in a rat model of spinal cord injury.{48407}
Specifications
CAS number
81944-09-4
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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