1-Oleoyl Glycerol

1-Oleoyl glycerol is a monoacylglycerol containing oleic acid (Item No. 90260) at the sn-1 position. 1-Oleoyl glycerol (10%), in a formulation with cyclosporin A (Item No. 12088) in propylene glycol, enhances diffusion of cyclosporin A from the donor compartment of a Franz diffusion cell into the stratum corneum, epidermis, and dermis of porcine ear skin, as well as through the skin to the receptor compartment.{48157} Mixed micellar systems containing 1-oleoyl glycerol and bile salts increase the apparent permeability coefficient (Papp) and absorption rate of amphotericin B (Item No. 11636) in perfused rat intestine in vivo.{48158} Formulations containing 1-oleoyl glycerol have been used as emulsifying agents, food additives, and absorption enhancers.