Product description
3-Aminoisobutyric acid is a non-protein amino acid formed during thymine catabolism.{47337} It induces browning in primary adipocytes, increasing the expression of uncoupling protein 1 (UCP-1) and CIDEA when used at a concentration of 5 µM. It also increases the expression of PPARa in primary adipocytes and in mouse inguinal white adipose tissue (WAT) in vivo and increases B-oxidation in hepatocytes. Plasma levels of 3-aminoisobutyric acid are increased in mice following exercise and, when administered at a dose of 100 mg/kg per day, it decreases weight gain and body fat percentage without decreasing food intake or increasing energy expenditure, and improves glucose tolerance. Levels of 3-aminoisobutyric acid are elevated in the plasma, urine, and cerebrospinal fluid of patients with B-ureidopropionase deficiency, a disorder characterized by an inborn error of pyrimidine degradation.{47338}
Specifications
CAS number
84796-61-2
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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3-Aminoisobutyric Acid (sodium salt)

26537-5

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3-Aminoisobutyric Acid (sodium salt)

26537-5

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