Product description
(E)-Ajoene is a disulfide that has been found in A. sativum and has diverse biological activities.{63181,63182,63183,63184} It is active against Gram-positive and Gram-negative bacteria (MICs = 10-250 and 150->500 µg/ml, respectively) and fungi (MICs = 15-50 µg/ml).{63181} (E)-Ajoene inhibits proliferation of a variety of cancer cells, including MDA-MB-231 breast, HeLa cervical, and WHCO1 esophageal cancer cells (IC50s = 18.6, 61, and 39.2 µM, respectively).{63182} It also inhibits human glutathione reductase and T. cruzi trypanothione reductase when used at a concentration of 200 µM.{63183} (E)-Ajoene (25 mg/kg) is neuroprotective in a gerbil model of ischemia-reperfusion injury, reducing reactive astrocytosis and microgliosis in the hippocampal CA1 region.{63184}
Specifications
CAS number
92284-99-6
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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