Product description
(+-)-Sulpiride is an atypical antipsychotic that binds to dopamine D2 and D3 receptors (Kis = 4.2 and 15 nM, respectively).{41323} It is selective for dopamine D2 and D3 over D1 receptors and the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2C, and 5-HT3 (Kis = >10,000 nM). (+-)-Sulpiride (0.5 or 1 ng per animal) increases attentional accuracy and decreases latency to respond correctly, the number of omissions, and impulsivity in the 5-choice serial reaction time task (5CSRTT) when infused directly into the nucleus accumbens in a rat model of prefrontal cortex lesion-induced attentional dysfunction.{46039} It increases cortical and striatal demethylation of hypermethylated reelin and GAD67 promoters in mice when administered at doses ranging from 12.5 to 50 ?mol/kg twice per day for three days.{46040} Formulations containing (+-)-sulpiride have been used in the treatment of schizophrenia.
Specifications
CAS number
15676-16-1
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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