Product description
(+-)10(11)-EDP ethanolamide is an w-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 0.43 and 22.5 nM for CB1 and CB2 receptors, respectively).{42488} It is produced though direct epoxygenation of docosahexaenoyl ethanolamide (DHEA; Item No. 10007534) by cytochrome P450 (CYP) epoxygenases.{42488,40186} 10,11-EDP epoxide (12.5 and 25 ?M) reduces the viability of 143B metastatic osteosarcoma cells.{42488} It induces apoptosis and inhibits cell migration in a wound-healing assay in 143B, MG63, and HOS osteosarcoma cells. (+-)10(11)-EDP ethanolamide also reduces tube formation by human umbilical vein endothelial cells (HUVECs) in a Matrigel™ assay.
Specifications
CAS number
2123484-71-7
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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(+-)10(11)-EDP Ethanolamide

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