Product description
17B-hydroxy Exemestane-d3 is intended for use as an internal standard for the quantification of 17B-hydroxy exemestane and as a surrogate internal standard for related steroids such as exemestane (Item No. 15008) by GC- or LC-MS. 17B-hydroxy Exemestane is the primary active metabolite of exemestane.{37747} It is formed by metabolism of exemestane by the cytochrome P450 (CYP) isoforms CYP1A and CYP4A11.{37748} 17B-hydroxy Exemestane is an aromatase inhibitor (IC50 = 69 nM using human placental microsomes) and an androgen receptor (AR) agonist (IC50 = 39.6 nM) that is selective for AR over estrogen receptor a (ERa; IC50 = 21.2 ?M).{37749,37750} It stimulates growth of AR- and ERa-positive MCF-7 (EC50 = 2.7 ?M) and T47D breast cancer cells (EC50s = 0.43 and 1,500 nM for AR- and ER-mediated growth, respectively) and inhibits proliferation of testosterone-treated aromatase-overexpressing MCF-7aro cells in a concentration-dependent manner.{37750,37751} 17B-hydroxy Exemestane (20 mg/kg) inhibits increases in serum cholesterol and LDL levels and prevents decreases in bone mineral density in the lumbar vertebrae and femur, as well as femoral bending strength and compressive strength of the fifth lumbar vertebrae, in ovariectomized rats.{37747}
Specifications
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

Order your product by email

Productname

17B-hydroxy Exemestane-d3

25756-500

By filling out this form, you are placing an order by e-mail. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.


Request a sample

Productname

17B-hydroxy Exemestane-d3

25756-500

By filling out this form, you request a sample. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.


Organization information

*Required fields


Are you looking for specific products, alternatives or documentation?