5a,6a-epoxy Cholestanol

5a,6a-epoxy Cholestanol is an oxysterol and a metabolite of cholesterol produced by oxidation.{45075} 5a,6a-epoxy Cholestanol accumulates in MCF-7 breast cancer cells in a reactive oxygen species-dependent manner following tamoxifen and PBPE application and induces triacylglycerol biosynthesis by binding to liver x receptor B (LXRB).{45076} 5a,6a-epoxy Cholestanol levels are increased in rat aorta and mesenteric artery following orchidectomy, an effect that can be prevented by a DHA-supplemented diet.{45075} Levels are also increased in post-mortem frontal and occipital cortex of patients with Alzheimer’s disease.{45077}