23-epi-26-Deoxyactein

23-epi-26-Deoxyactein is a triterpene glycoside and a major constituent of black cohosh (C. racemosa).{43486,43487} It reduces intracellular calcium concentrations, collapse of the mitochondrial membrane potential, production of reactive oxygen species (ROS), and cardiolipin peroxidation and inhibits autophagy and apoptosis in osteoblastic MC3T3-E1 cells induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).{43486} 23-epi-26-Deoxyactein (0.01-10 ?M) reduces production of ROS and IL-1B and cell death induced by methylglyoxal in RIN-m5F B-cells.{43487}