1,3-Dicaffeoylquinic Acid

1,3-Dicaffeoylquinic acid is a polyphenol that has been found in C. scolymus.{47054} It decreases the expression and protein levels of inducible nitric oxide synthase (iNOS) when used at a concentration of 10 µM in human coronary artery smooth muscle cells (HCASMCs) treated with a cytokine mixture.{47055} 1,3-Dicaffeoylquinic acid decreases protein levels of tyrosinase and microphthalmia-associated transcription factor (MITF) in B16F1 murine melanocytes.{47056} It inhibits melanogenesis in B16F1 cells and decreases tyrosinase activity in cell lysates when used at a concentration of 25 µM.{47054} 1,3-Dicaffeoylquinic acid (20 and 40 µM) reduces triglyceride levels in sodium oleate-induced hyperlipidemic HepG2 cells compared to hyperlipidemic control cells.