(-)-Catechin Gallate

(-)-Catechin gallate ((-)-CG) is a catechin polyphenol that has been found in green tea extracts with diverse biological activities.{41817,41815,41818,41816} It inhibits proliferation of MDA-MB-231 breast cancer cells and reduces VEGF-induced tyrosine phosphorylation of VEGF receptor 2 (VEGFR2) in bovine aortic endothelial cells (BAECs) in a concentration-dependent manner.{41817,41815} (-)-CG is a competitive inhibitor of the facilitative glucose transporter GLUT4 (Ki = 90 ?M) and inhibits methylglucose uptake by isolated rat adipocytes (IC50 = 50 ?M).{41818} It is also lytic against T. cruzi amastigotes, with a 50% bactericidal concentration (MBC50) value of 48 pM.{41816}