Product description
(-)-Securinine is an alkaloid originally isolated from S. suffructicosa.{42132} It reduces proliferation of SW480 colon adenocarcinoma cells in a dose- and time-dependent manner via increased Beclin 1 expression and induction of autophagy.{42133} It decreases viability of HL-60 leukemia cells (IC50s = 47.88, 23.85, and 18.87 ?M at 24, 48, and 72 hours post-treatment, respectively).{42134} It also induces cell cycle arrest at the G1/S phase and decreases PI3K, Akt, and mTOR gene expression in a dose-dependent manner. (-)-Securinine inhibits GABA and GABA-activated benzodiazepine binding to rat brain membranes (IC50s = 57 and 101 ?M, respectively).{42132} In vivo, (-)-securinine (5.2 mg/kg) induces clonic and tonic convulsions in mice, an effect that is reversed by administration of GABA.{42135}
Specifications
CAS number
5610-40-2
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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