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4-hydroxy Alternariol
23636-5
5 mg
€2057
Product description
4-hydroxy Alternariol is a metabolite of the mycotoxin alternariol (Item No. 11306) formed through cytochrome P450 (CYP450) metabolism.{41226} It increases reactive oxygen species (ROS) in KYSE510 human esophageal cells by 701% compared to control.{41227} 4-hydroxy Alternariol increases topoisomerase IIB-DNA complexes by 208% compared to control in an ICE assay but does not induce DNA damage in KYSE510 cells. It completely inhibits topoisomerase IIa activity at a concentration of 25 µM under cell-free conditions.
Specifications
CAS number
959417-21-1
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C
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4-hydroxy Alternariol
23636-5
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