Product description
7ACC2 is a carboxycoumarin inhibitor of monocarboxylate transporter 1 (MCT1) with an IC50 value of 10 nM for lactate uptake, an MCT1-dependent process, in SiHa human cervix carcinoma cells.{36195} It inhibits proliferation of SiHa cells in the presence of lactate in a dose-dependent manner but lacks cytotoxicity in the presence of glucose. 7ACC2 also inhibits the mitochondrial pyruvate carrier (MPC) in a concentration- and time-dependent manner in isolated tumor cell mitochondria.{46097} In vivo, 7ACC2 (3 mg/kg) increases intratumor lactate accumulation and decreases tumor size in an SiHa mouse xenograft model.
Specifications
CAS number
1472624-85-3
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

Order your product by email

Productname

7ACC2

23445-5

By filling out this form, you are placing an order by e-mail. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.


Request a sample

Productname

7ACC2

23445-5

By filling out this form, you request a sample. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.


Organization information

*Required fields


Are you looking for specific products, alternatives or documentation?