5-(Hydroxymethyl)-2’-deoxyuridine

5-(Hydroxymethyl)-2’-deoxyuridine is a nucleoside analog with anticancer and antiviral activities.{38403} It inhibits the replication of murine S180 lung carcinoma cells and Ehrlich ascites mammary carcinoma cells (ED50s = 8.5 and 4 ?M, respectively) and multiple human leukemia cell lines (IC50s = 1.7-5.8 ?M).{38403,38404} 5-(Hydroxymethyl)-2’-deoxyuridine acts synergistically with 5-fluorouracil (5-FU; Item No. 14416) against HT-29, HCT116, PANC-1, and EKVX cancer cells with no effect on WI38 embryonic lung fibroblasts.{38405} It inhibits herpes simplex virus type 1 (HSV-1) pyrimidine 2’-deoxyribonucleoside kinase (Ki = 3.5 ?M) and reduces HSV-1 viral titer to 0.05% of the control at a concentration of 200 ?M.{38403} 5-(Hydroxymethyl)-2’-deoxyuridine is also a DNA adduct, formed in response to oxidative stress, that is found in hepatic DNA of rats treated with gamma irradiation, diethylnitrosamine, 2-acetylaminofluorene, and ciprofibrate (Item No. 18515).{38406}