(+)-Valencene

(+)-Valencene is a sesquiterpene that has been found in C. sativa and is an aromatic component of orange essence oil.{43235,43243} (+)-Valencene (50 µM) induces heme oxgenase-1 (HO-1) expression in macrophages and inhibits the expression of inducible nitric oxide synthase (iNOS), the production of nitric oxide (NO), and the release of high-mobility group box-1 (HMGB1) in RAW 264.7 cells stimulated with LPS.{43244} It also increases the survival rate in a mouse model of sepsis induced by cecal ligation and puncture. (+)-Valencene has been used in the synthesis of nootkatone (Item No. 24910).{43245}