Product description
740 Y-P is a synthetic phosphopeptide activator of PI3K.{37145,68293} It contains amino acids from the Antennapedia protein, which acts as a cellular internalization sequence, followed by a sequence from PDGFR that is recognized by the SH2 domain of PI3K.{37145} 740 Y-P (15 µM) increases phosphorylation of PI3K, mammalian target of rapamycin (mTOR), and glycogen synthase kinase 3B (GSK3B) in HepG2 hepatocellular carcinoma cells.{68293} It prevents glucose-oxygen deprivation-induced decreases in viability of primary rat hippocampal cells in an in vitro model of ischemia when used at a concentration of 1 µM.{68294} 740 Y-P (1 µM), in combination with the thrombopoietin receptor (TPOR) agonist butyzamide, hematopoietic stem cell (HSC) self-renewal agonist UM171, and polymer PCL-PVAc-PEG, has been used to expand isolated human umbilical cord blood HSCs ex vivo for up to 30 days.{68295}
Specifications
CAS number
1236188-16-1
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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740 Y-P

22598-1

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