Product description
4µ8C is an inhibitor of inositol requiring enzyme 1 a (IRE1a), which is a protein located in the endoplasmic reticulum (ER) membrane that has kinase and RNase activities triggered by ER stress.{39181} 4µ8C inhibits IRE1a splicing of Xbp1 mRNA (IC50 = 6.8 µM) and reduces subsequent gene expression of Erdj4 (IC50 = 3.4 µM) in stress-cultured MEF cells but does not block IRE1a autophosphorylation. It reduces IL-4 production in CD4+ T cells isolated from murine spleen and LPS-stimulated increases in TNF-a and IL-6 mRNA expression and protein secretion in isolated alveolar macrophages from patients with cystic fibrosis.{39182,39183}
Specifications
CAS number
14003-96-4
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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22110-10

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