Product description
6-hydroxy Bexarotene is an oxidative metabolite of bexarotene (Item No. 11571), a high-affinity ligand for retinoid X receptors (RXRs).{35324} 6-hydroxy Bexarotene binds to RXRa, RXRB, and RXRy as well as retinoic acid receptor a (RARa; Kds = 3.46, 4.21, 4.83, and 8.17 ?M, respectively). It selectively activates RXRa, RXRB, and RXRy over RARa, RARB, and RARy in vitro (EC50s = 398, 356, 420, 4,414, 2,121, and 2,043 nM, respectively).
Specifications
CAS number
368451-07-4
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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