4'-hydroxy Flurbiprofen

4'-hydroxy Flurbiprofen is a major active metabolite of the COX inhibitor flurbiprofen (Item No. 70250) and its enantiomers (R)-flurbiprofen (Item No. 70255) and (S)-flurbiprofen (Item No. 10004207).{48402} It is formed from flurbiprofen by the cytochrome P450 (CYP) isoform CYP2C9, including CYP2C9 containing an R144C substitution mutation. 4’-hydroxy Flurbiprofen inhibits COX-1 by 94% at a concentration of 1,000 µM but does not inhibit cyclooxygenation of arachidonic acid.{48403} It completely inhibits cyclooxygenation of 2-arachidonoyl glycerol (2-AG; Item No. 62160) when used at a concentration of 300 µM. 4'-hydroxy Flurbiprofen inhibits fatty acid amide hydrolase (FAAH) hydrolysis of anandamide in rat brain homogenates with an IC50 value of 84 µM at a pH of 6.