(+-)-Linalool

(+-)-Linalool is a monoterpene alcohol that has been found in C. sativa, C. indica, and hemp with diverse biological activities.{41453,21575,36770,36771,36772,42327} It induces cell cycle arrest at the G0/G1 and G2M phase in U937 and HeLa cells, respectively.{21575} (+-)-Linalool is cytotoxic to U937 and HeLa cells (IC50s = 2.59 and 11.02 ?M, respectively). It induces recruitment of a PGC-1a coactivator peptide to the PPARa ligand binding domain (EC50 = 5.45 ?M in a TR-FRET assay).{36770} In vivo, (+-)-linalool reduces plasma triglyceride concentration in mice fed a Western diet and transgenic mice expressing human ApoE2, but not PPARa-/- mice. It has molluscicidal and larvicidal effects in vitro (LC50s = 0.25 and 0.07 mg/L for O. hupensis and S. japonicium, respectively), and it reduces the amount of schitosomulum recovered from mouse skin after S. japonicium challenge infection.{36771} (+-)-Linalool (10-40 mg/kg) reduces the number of macrophages and neutrophils and the production of TNF-a, IL-6, IL-1B, IL-8, and MCP-1 in bronchoalveolar lavage fluid (BALF) in a mouse model of cigarette smoke-induced acute lung inflammation.{36772} It also decreases immobility time in the forced swim test in mice, indicating antidepressant-like activity.{42327}