Product description
(E/Z)-Endoxifen is an active metabolite of tamoxifen (Item No. 13258) produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6.{29622,28212,29623} It is a strong anti-estrogen, as it has an approximately 100-fold greater affinity for estrogen receptors than tamoxifen.{29622} As the efficient conversion of tamoxifen to endoxifen depends on CYP2D6, polymorphisms in this CYP isoform can impact the effectiveness of TMX treatment.{29622,28212,29623}
Specifications
CAS number
110025-28-0
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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