(E)-5-(2-Bromovinyl)uracil

(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo.{42576,42577,42575} BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner.{42576,42578} It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil (5-FU; Item No. 14416) in a P388 murine leukemia model when administered at a dose of 200 µmol/kg, increasing survival time.{42578}