Product description
2-PMAP is an inhibitor of the production of amyloid precursor protein (APP) and amyloid-B (AB) secretion.{48316} It reduces levels of APP and its intracellular C-terminal fragments a-CTF and B-CTF in CHO APP751SW cells when used at a concentration of 10 ?M. 2-PMAP also reduces secretion of AB (1-40) and AB (1-42) by 88.6 and 84.9%, respectively, in CHO APP751SW cells when used at a concentration of 50 ?M without inducing cellular toxicity. In vivo, 2-PMAP reduces brain levels of full-length APP, a-CTF and B-CTF, and soluble AB (1-40) and AB (1-42) in the APPSWPS1dE9 transgenic mouse model of Alzheimer's disease. It also improves novel object memory as well as spatial memory in the radial arm maze in APPSWPS1dE9 transgenic mice.
Specifications
CAS number
102212-26-0
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

Order your product by email

Productname

2-PMAP

21021-1

By filling out this form, you are placing an order by e-mail. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.


Request a sample

Productname

2-PMAP

21021-1

By filling out this form, you request a sample. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.


Organization information

*Required fields


Are you looking for specific products, alternatives or documentation?