5'-chloro-5'-Deoxyadenosine (hydrate)

5'-chloro-5'-Deoxyadenosine (hydrate) is a nucleoside analog used as a substrate in polyketide biosynthesis. S-(5’-adenosyl)-L-methionine (SAM; Item No. 13956) can be converted to 5’-chloro-5’-deoxyadenosine in a reaction catalyzed by a SAM-dependent chlorinase.{32994} Through a 7-step route, 5'-chloro-5'-deoxyadenosine can be converted to chloroethylmalonyl-CoA, which has been shown to be involved in the biosynthesis of the anticancer agent salinosporamide A (Item No. 10007311) in the marine bacterium S. tropica.{32994}