Product description
5,6-dihydro-5-Fluorouracil is an active metabolite of the thymidylate synthase inhibitor prodrug 5-fluorouracil (Item No. 14416).{34391} It is formed from 5-fluorouracil by dihydropyrimidine dehydrogenase (DPD). 5,6-dihydro-5-Fluorouracil is cytotoxic to HaCaT keratinocytes (IC50 = 13.5 µM). Intravenous administration of 5,6-dihydro-5-fluorouracil (90 mg/kg per week), in combination with 5-fluorouracil and the DPD inhibitor eniluracil (Item No. 34251), reduces tumor growth in a rat model of colon carcinoma.{65608}
Specifications
CAS number
696-06-0
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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