Product description
17a-Estradiol is the natural optical isomer of 17B-estradiol (Item No. 10006315), the major estrogen secreted by the premenopausal ovary. 17a-Estradiol is a less active isomer than its counterpart, displaying 100-fold lower estrogenic activity relative to 17B-estradiol.{24968} It can inhibit 5a-reductase, which plays a role in regulating hair growth. 17a -estradiol is reported to activate the MAPK/ERK and PI3K-Akt signaling pathways via activation of the estrogen receptor-X and has been shown to be neuroprotective after an ischemic stroke and oxidative stress and in transgenic mice with Alzheimer’s disease.{24968,13837}
Specifications
CAS number
57-91-0
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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