Product description
7B,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor y (RORy) and RORyt.{33003} It activates RORy- or RORyt-dependent signaling with EC50 values of 691 and 1,045 nM, respectively, in reporter assays using HEK293T cells expressing the recombinant human receptors. 7B,27-dihydroxy Cholesterol is selective for RORy and RORyt over a panel of eight additional nuclear receptors at 30 µM. It increases IL-17A production in Th17-polarized isolated human naïve CD4+ T cells when used at a concentration of 300 nM. 7B,27-dihydroxy Cholesterol (60 mg/kg) increases IL-17A production in isolated mouse yd T cells stimulated with 12-myristate 13-acetate (PMA; Item No. 10008014) and ionomycin (Item Nos. 10004974 | 11932).
Specifications
CAS number
240129-43-5
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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7B,27-dihydroxy Cholesterol

20102-1

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7B,27-dihydroxy Cholesterol

20102-1

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