5-hydroxy-N?-methyl Tryptamine is a metabolite of serotonin (5-HT; Item No. 14332) in humans that has also been found in plants.{48185,31973,42693} It is an agonist of the 5-HT receptor subtype 5-HT7 (IC50 = 23 pM in a radioligand binding assay).{31973} 5-hydroxy-N?-methyl Tryptamine increases intracellular cyclic AMP production in HEK293 cells expressing 5-HT7 (EC50 = 22 nM). It inhibits serotonin uptake in HEK293 cells expressing human serotonin transporters (IC50 = 490 nM). Elevated levels of urinary 5-hydroxy-N?-methyl tryptamine have been found in patients with schizophrenia, depression, and epilepsy.{48185}
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Cayman Chemical
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