Product description
The CD8a (CD8 alpha) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.
Specifications
Applications
FC
Host
Rat
Clonality
Monoclonal
Clone
53-6.7
Isotype
Rat IgG2a kappa
Supplier
Exbio
Shipping & storage
Storage temperature
2-8°C

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Rat Monoclonal to CD8a (mouse), Clone 53-6.7, FITC

1F-579-C100

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Productname

Rat Monoclonal to CD8a (mouse), Clone 53-6.7, FITC

1F-579-C100

By filling out this form, you request a sample. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.


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