Product description
a-Hydroxyglutaric acid (2-HG; Item No. 16374) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder.{26770,26771,26772} Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2, typically associated with certain cancers, can cause these enzymes to convert isocitrate to 2-HG, rather than a-ketoglutarate.{26773,26775} 2-HG is structurally similar to a-ketoglutarate and competitively inhibits a-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases.{26775,26774,26769} (2R)-Octyl-a-hydroxyglutarate-d17 is intended for use as an internal standard for the quantification of (2R)-octyl-a-hydroxyglutarate (Item No. 16366) by GC- or LC-MS. (2R)-Octyl-a-hydroxyglutarate is a cell-permeable derivative of the D-isomer of 2-HG. It has been used to examine the contribution of D-2-HG to the oxidative mitochondrial processes of IDH1-mutated cancer cells.{28419}
Specifications
CAS number
2748638-78-8
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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(2R)-Octyl-a-hydroxyglutarate-d17

19694-1

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(2R)-Octyl-a-hydroxyglutarate-d17

19694-1

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