Product description
7BIO is a derivative of indirubin (Item No. 14155) that triggers a rapid cell death process that is distinct from apoptosis and devoid of cytochrome c release or caspase activation.{31285} Furthermore, in contrast to other indirubin derivatives, 7BIO has only marginal activity against the classic indirubin targets, cyclin-dependent kinases and GSK3.{31285,22470} Instead, 7BIO inhibits FLT3 (IC50 = 0.34 µM) and the dual-specificity tyrosine phosphorylation-regulated kinases, DYRK1A and DYRK2 (IC50s = 1.9 and 1.3 µM, respectively).{31285,31284} It also inhibits Aurora B and C kinases with IC50 values of 4.6 and 0.7 µM, respectively.{31285,31283}
Specifications
CAS number
916440-85-2
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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