Product description
6-thio-2?-Deoxyguanosine (6-thio-dG) is a purine nucleoside analog. It reduces infection of Calu-3 cells by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; EC50 = 0.04 µM) but is also toxic to Calu-3 cells with a 50% cytotoxic concentration (CC50) value of 1.14 µM.{64537} 6-Thio-dG (2 mg/kg) decreases tumor volume and increases the number of tumor cells with telomere dysfunction-induced foci in an A549 non-small cell lung cancer (NSCLC) mouse xenograft model.{31123} It increases the number of programmed cell death protein 1 (PD-1) positive CD8+ T cells, as well as induces tumor regression when administered in combination with an antibody against PD-1 ligand (PD-L1) in MC-38 murine colon carcinoma models.{67152}
Specifications
CAS number
789-61-7
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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6-thio-2?-Deoxyguanosine

19154-5

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6-thio-2?-Deoxyguanosine

19154-5

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