Product description
2-Acetylphenothiazine (2-APT) is a selective, cell-active inhibitor of NADPH oxidase 1 (NOX1) that blocks the generation of reactive oxygen species (ROS) in HT-29 cells with an IC50 value of 0.129 µM.{31204} It does not affect xanthine oxidase-dependent or mitochondrial ROS generation.{31204} 2-APT prevents ROS-dependent formation of ECM-degrading invadopodia in colon cancer cells.{31204} It also abolishes collagen-induced superoxide production by platelets (IC50 = 306 nM), preventing platelet aggregation and thrombus formation.{31206} 2-APT protects beta cells from cytokine-induced apoptosis by inhibiting NOX1.{31207} 2-APT can also activate the human transient receptor potential ankyrin 1 (TRPA1) nociceptor at 1-30 µM.{31205}
Specifications
CAS number
6631-94-3
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Blue Ice
Storage temperature
2-8°C

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