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Rat Anti-Mouse CD122-APC
1905-11
0,1 mg
€369
Product description
The IL-2 receptor is a complex of three distinct polypeptide chains: (i) the ? chain which binds IL-2 with low affinity; (ii) the ? chain that binds IL-2 with high affinity; and (iii) the common ? chain (?c) that does not bind IL-2. The high affinity receptor complex is an ?/?/? heterotrimer with a Kd of 1.3 x 10-11 M. In mouse spleen, CD122 is expresed on ~30% of CD8+ cells and all NK cells but <1% of B cells and CD4+ T lymphocytes. In the thymus, its expression is confined to CD4-CD8+ single positive and CD4-CD8- double negative cells. Cytoplasmic regions of the IL-2R ? chain are involved in IL-2-mediated cellular signaling and, via the interaction of IL-2 and its receptor complex, may be involved in the generation and differentiation of T lymphocytes. The monoclonal antibody 5H4 does not block IL-2 binding.
Specifications
Applications
FC
Host
Rat
Clonality
Monoclonal
Clone
5H4
Isotype
IgG2a
Supplier
Southern Biotech
Shipping & storage
Shipping condition
Room Temperature
Storage temperature
2-8°C
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Rat Anti-Mouse CD122-APC
1905-11
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Rat Anti-Mouse CD122-APC
1905-11
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