Product description
11B-13,14-dihydro-15-keto Prostaglandin F2a-d9 (11B-13,14-dihydro-15-keto PGF2a-d9) is intended for use as an internal standard for the quantification of 11B-13,14-dihydro-15-keto PGF2a (Item No. 16540) by GC- or LC-MS. 11B-13,14-dihydro-15-keto PGF2a is a metabolite of prostaglandin D2 (PGD2; Item No. 12010) in the 15-hydroxy PGDH pathway.{11174,11176} Infusion or inhalation of tritiated PGD2 in normal males results in the appearance of peak levels of both 11B-PGF2a, as the immediate product, and 11B-13,14-dihydro-15-keto PGF2a in the plasma within 10 minutes.{11174} Homogenates of human lung metabolize PGD2 first to 11B-PGF2a and then to 11B-15-keto-PGF2a in the presence of NAD+, but not 11B-13,14-dihydro-15-keto PGF2a.{11176} Guinea pig liver and kidney homogenates metabolize PGD2 to 11B-13,14-dihydro-15-keto PGF2a, via 11B-PGF2a, in the presence of NAD+ and NADP+.{11176}
Specifications
CAS number
2738376-88-8
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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11B-13,14-dihydro-15-keto Prostaglandin F2a-d9

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11B-13,14-dihydro-15-keto Prostaglandin F2a-d9

18787-50

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