8-bromo-Cyclic AMP

8-bromo-Cyclic AMP is an activator of protein kinase A (PKA) with a half-maximal activation (Ka) value of 0.05 µM.{22886} It is selective for PKA over cGMP-dependent protein kinase (PKG; Ka = 5.8 µM) and is more resistant to hydrolysis by phosphodiesterases (PDEs) compared with cAMP (Item No. 18820).{22886,26218} 8-bromo-Cyclic AMP inhibits the proliferation of HL-60 leukemia cells (IC50 = 18 µM after six days).{26218} It induces relaxation of isolated rabbit carotid or renal arterial rings precontracted with phenylephrine when used at concentrations ranging from 10 to 300 µM.{51185} Intradermal administration of 8-bromo-cyclic AMP (10 nmol/site) prevents scratching and increases in cutaneous leukotriene B4 (LTB4) production induced by the proteinase-activated receptor 2 (PAR2) agonist SLIGRL-NH2 (Item No. 16723) in mice.{53586}