Product description
SET domain-containing protein 7/9 (SET7/9) is a histone methyltransferase that monomethylates lysine 4 of histone H3, which generates a specific tag for epigenetic transcriptional activation. It plays a role in the transcriptional activation of tumor suppressor p53 in response to DNA damage, as well as the transcription factor TAF10(Item No. 10228).{16846,17223} (R)-PFI-2 (Item No. 14678) is a potent, cell-permeable inhibitor of SET7/9 (IC50 = 2 nM) that demonstrates greater than 1,000-fold selectivity over a panel of 18 other methyltransferases.{26909} (S)-PFI-2, the inactive enantiomer, is 500-fold less potent (IC50 = 1 µM) and may serve as a negative control.{26909} See the Structural Genomics Consortium (SGC) website for more information.
Specifications
CAS number
1627607-88-8
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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(S)-PFI-2 (hydrochloride)

18119-5

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(S)-PFI-2 (hydrochloride)

18119-5

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