Product description
3,3',5’-Triiodo-L-thyronine, also known as reverse T3 (rT3), is a thyroid hormone generated by deiodination of the prohormone thyroxine. It is about 1,000-fold less active at the thyroid hormone receptors TRa and TRB than 3,3',5-triiodo-L-thyronine (Item No. 16028) and commonly described as inactive.{28789,28791} However, high serum levels of rT3 are found in neonates and in certain conditions.{28795,28793,28790,28792} It reportedly activates TRda1, a native form of TRa that lacks a nuclear localization signal and functions in the cytoplasm.{28794} Through this action, rT3 initiates actin polymerization, particularly in astrocytes and neurons.{28794}
Specifications
CAS number
5817-39-0
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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3,3',5'-Triiodo-L-thyronine

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