Product description
(5Z)-7-Oxozeaenol is a resorcylic acid lactone fungal metabolite and an inhibitor of TGF-B activated kinase 1 (TAK1; IC50 = 8.1 nM in the presence of TAK1-binding protein 1 (TAB1)).{28252} It is selective for TAK1 over MEK1 and MEKK1 (IC50s = 411 and 268 nM, respectively), as well as apoptosis signal-regulating kinase 1 (ASK1) and IkB kinase B (IKKB) at 300 nM. (5Z)-7-Oxozeaenol inhibits NF-kB activity in a reporter assay using HEK293 cells expressing TAK1 and TAB1 (IC50 = 83 nM) and reduces IL-1-induced increases in COX-2 levels in mouse embryonic fibroblasts (MEFs). It sensitizes HeLa cells to apoptosis induced by TNF-related apoptosis-inducing ligand (TRAIL) when used at a concentration of 300 nM and induces necroptosis when used in combination with TNF and zVAD in primary mouse bone marrow-derived macrophages (BMDMs) at 100 nM.{28253,64844} Topical application of (5Z)-7-oxozeaenol (10 µl of a 1 mg/ml solution) prevents picryl chloride-induced increases in ear thickness in mice.{28252}
Specifications
CAS number
253863-19-3
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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