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(E/Z)-4-hydroxy Tamoxifen
17308-5
5 mg
€40
Product description
(E/Z)-4-hydroxy Tamoxifen is an active metabolite of tamoxifen (Item No. 13258).{28446} It is formed from tamoxifen by the cytochrome P450 (CYP) isoform CYP2D6. (E/Z)-4-hydroxy Tamoxifen is cytotoxic to MCF-7 and MDA-MB-231 breast cancer cells (IC50s = 27 and 18 µM, respectively).{28444} It also stimulates LC3 lipidation and the formation of autophagic vesicles in MCF-7 cells in a superoxide-dependent manner.{28445}
Specifications
CAS number
68392-35-8
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C
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17308-5
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17308-5
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