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Rat Anti-Mouse CD71-LE/AF
1720-14
0,5 mg
€392
Product description
CD71, a type II transmembrane glycoprotein expressed on the cell surface as a homodimer, is the transferrin receptor. It is essential for the growth of normal and neoplastic cells. It is expressed at low levels on resting B and T lymphocytes but is upregulated during responses to antigens and mitogens presumably reflecting the iron dependence of proliferation. Its expression declines with maturation and differentiation. CD71 plays a critical role in cell proliferation by controlling the supply of iron which is essential for many metabolic pathways through the binding and endocytosis of transferrin, the major iron-carrying protein. It may also be involved in signal transduction via its association with the T cell receptor ? chain. The monoclonal antibody RI7217 inhibits cell proliferation in vitro.
Specifications
Applications
FC, IP, WB, ICC
Host
Rat
Clonality
Monoclonal
Clone
RI7217
Isotype
IgG2a
Supplier
Southern Biotech
Shipping & storage
Shipping condition
Blue Ice
Storage temperature
2-8°C
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Rat Anti-Mouse CD71-LE/AF
1720-14
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Rat Anti-Mouse CD71-LE/AF
1720-14
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