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Rat Anti-Mouse CD54/ICAM-1-LE/AF
1701-14
0,5 mg
€398
Product description
CD54, a member of the immunoglobulin superfamily of cell surface receptors and also known as Intercellular Adhesion Molecule-1 (ICAM-1), is a type I transmembrane glycoprotein that mediates important cell/cell interactions. CD54 is expressed on endothelial cells, dendritic cells, keratinocytes, and lymphocytes. Its expression is upregulated by inflammatory mediators such as IFN ?, IL-1, TNF-?, lipopolysaccharide, and phorbol esters. Endothelial CD54 contributes to the extravasation of leukocytes from blood vessels, particularly in areas of inflammation. CD54 on antigen-presenting cells contributes to antigen-specific T-cell activation, presumably by enhancing interactions between T cell and antigen-presenting cells. These adhesion reactions are mediated via the binding of CD54 to its major ligands, LFA-1 and Mac-1.
Specifications
Applications
FC, IP, IHC, WB, ICC
Host
Rat
Clonality
Monoclonal
Clone
YN1/1.7.4
Isotype
IgG2b
Supplier
Southern Biotech
Shipping & storage
Shipping condition
Blue Ice
Storage temperature
2-8°C
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Rat Anti-Mouse CD54/ICAM-1-LE/AF
1701-14
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Rat Anti-Mouse CD54/ICAM-1-LE/AF
1701-14
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