17-trifluoromethylphenyl trinor Prostaglandin F2a

A number of 17-phenyl trinor prostaglandin F2a (17-phenyl trinor PGF2a) derivatives have been approved for the treatment of glaucoma.{8941,9341,8839} Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists.{9668} 17-trifluoromethylphenyl trinor PGF2a bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trinor PGF2a would act very much like the free acid of travoprost. 17-phenyl trinor PGF2a is a potent luteolytic and abortifacient, with a potency equal to or greater than fluprostenol and cloprostenol.{9668}