Product description
15(R)-17-phenyl trinor Prostaglandin F2a isopropyl ester (15(R)-17-phenyl trinor PGF2a isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (B) hydroxyl group at C-15. Similar to 15(S)-latanoprost, 15(R)-17-phenyl trinor PGF2a isopropyl ester is a potential impurity in most commercial preparations of the latanoprost bulk drug product. The IC50 values for the free acid forms of 15(S)-17-phenyl trinor PGF2a and 15(R)-17-phenyl trinor PGF2a were determined to be 0.71 nM and 30 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle.{9736} A 3 µg dose of 15(R)-17-phenyl trinor PGF2a caused a 1.9 mmHg reduction of IOP in normotensive cynomolgus monkeys.{9736}
Specifications
CAS number
130273-87-9
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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15(R)-17-phenyl trinor Prostaglandin F2a isopropyl ester

16825-10

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15(R)-17-phenyl trinor Prostaglandin F2a isopropyl ester

16825-10

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